CONFORMATIONAL STUDIES OF TACHYKININ PEPTIDES USING NMR SPECTROSCOPY
Conformational analysis of two tachykinin family peptides: Scyliorhinin I (Seyl) and Scyliorhinin II (Scyll) was carried out by 1D- and 2D NMR (DQF-COSY, TOCSY, HMQC, HMBC, NOESY and ROESY) and molecular dynamics calculation methods in water and DMSO.Scyliorhinin I Beginner+ / Intermediate is a equipment agonist ofNK-1 and NK-2 taehykinin receptors